Identifying Phase-Amplitude Coupling in Cyclic Alternating Pattern using Masking Signals
نویسندگان
چکیده
Judiciously classifying phase-A subtypes in cyclic alternating pattern (CAP) is critical for investigating sleep dynamics. Phase-amplitude coupling (PAC), one of the representative forms of neural rhythmic interaction, is defined as the amplitude of high-frequency activities modulated by the phase of low-frequency oscillations. To examine PACs under more or less synchronized conditions, we propose a nonlinear approach, named the masking phase-amplitude coupling (MPAC), to quantify physiological interactions between high (α/lowβ) and low (δ) frequency bands. The results reveal that the coupling intensity is generally the highest in subtype A1 and lowest in A3. MPACs among various physiological conditions/disorders (p < 0.0001) and sleep stages (p < 0.0001 except S4) are tested. MPACs are found significantly stronger in light sleep than deep sleep (p < 0.0001). Physiological conditions/disorders show similar order in MPACs. Phase-amplitude dependence between δ and α/lowβ oscillations are examined as well. δ phase tent to phase-locked to α/lowβ amplitude in subtype A1 more than the rest. These results suggest that an elevated δ-α/lowβ MPACs can reflect some synchronization in CAP. Therefore, MPAC can be a potential tool to investigate neural interactions between different time scales, and δ-α/lowβ MPAC can serve as a feasible biomarker for sleep microstructure.
منابع مشابه
Analysis of Oscillation Amplitude and Phase Error in Multiphase LC Oscillators
Abstract This work proposes a novel method to find the phase error and oscillation amplitude in multiphase LC oscillators. A mathematical approach is used to find the relationship between every stage's output phase and its coupling factor. To much more general analysis, every stage assumed to have a different coupling factor. The mismatches in LC tanks are considered as the main source of pha...
متن کاملGait Generation for a Bipedal System By Morris-Lecar Central Pattern Generator
The ability to move in complex environments is one of the most important features of humans and animals. In this work, we exploit a bio-inspired method to generate different gaits in a bipedal locomotion system. We use the 4-cell CPG model developed by Pinto [21]. This model has been established on symmetric coupling between the cells which are responsible for generating oscillatory signals. Th...
متن کاملPhase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses.
Interactions between neural oscillations in the brain have been observed in many structures including the hippocampus, amygdala, motor cortex, and basal ganglia. In this study, one popular approach for quantifying oscillation interactions was considered: phase-amplitude coupling. The goals of the study were to use simulations to examine potential causes of elevated phase-amplitude coupling in p...
متن کاملCyclic alternating pattern
Key points • Expressed by the physiological phasic events of NREM sleep, including arousals, cyclic alternating pattern represents the most complex arrangement of sleep microstructure. • Cyclic alternating pattern is organized in sequences organized in successive cycles. Each cyclic alternating pattern cycle is composed of a phase A (phasic events) and a phase B (background rhythm). • Cyclic al...
متن کاملTranslation Invariant Approach for Measuring Similarity of Signals
In many signal processing applications, an appropriate measure to compare two signals plays a fundamental role in both implementing the algorithm and evaluating its performance. Several techniques have been introduced in literature as similarity measures. However, the existing measures are often either impractical for some applications or they have unsatisfactory results in some other applicati...
متن کامل